The Senate on Tuesday voted to block the Clarity Act from advancing, dealing a major blow to the crypto industry’s push for a comprehensive market structure framework.

The procedural vote leaves the bill stalled on Capitol Hill after months of negotiations aimed at building bipartisan support. Republican leaders had released a revised version of the bill Sunday, adding new ethics restrictions to address Democratic concerns about public officials profiting from crypto ventures. Those changes weren’t enough, however, to resolve the remaining opposition.

The vote was a stunning loss for the crypto industry, which had exuded confidence that enough senators would vote to advance the bill. Leading up to the vote, Democrats expressed…