WASHINGTON, Sept 16 : The U.S. Senate’s vote against advancing a major crypto bill amid persistent opposition from Democrats and a handful of Republicans marks one of the most significant setbacks for the industry, showing the limits of its muscle in Washington.

Senators on Tuesday voted 49-50 against advancing the Clarity Act, which would establish a regulatory framework for the $2 trillion cryptocurrency market, putting the industry on a firmer legal footing, with four Republicans voting against. Crypto companies say the bill is crucial to their future in the U.S.

The defeat came even after the industry spent more than $300 million combined on the 2024 and 2026 elections to push crypto policy into the political mainstream by getting…