‘Investing’ in CTOs With Staged PCI Seems to Pay Off in Safety Gains

The single-arm INVEST-CTO study showed high procedural success with a two-part intervention, but questions remain.

SAN FRANCISCO, CA—Among patients with anatomically high-risk chronic total occlusion (CTO) lesions, a two-part staged intervention consisting of an initial modification and a secondary completion procedure may improve procedural success and safety outcomes, according to the INVEST-CTO study.

The “investment” procedure, which resulted in 86.7% procedural success with no in-hospital MACE, starts with a planned modification of the proximal cap, occlusive segment, and distal cap with a noncompliant balloon, with no attempt at reentry or retrograde wiring. Patients return 8 to 12 weeks later for the…

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